What is Cilanem 1gm Injection?
Cilanem 1gm Injection is a combination of antibiotic medicines which consist of Imipenem 1000mg and Cilastatin 1000mg. Originally sold under the brand name Primaxin, brand we sell in BudgetGenerics.com is Cilanem 1gm Injection. This medicine is prescribed to treat various types of severe bacterial infections. It fights against the infection-causing microorganisms to prevent further infections. Usually prescribed for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. Dosage is usally injected into a vein or muscle.
Recommendations for use of Cilanem 1gm Injection
This medication is a broad spectrum beta-lactam antibiotic, prescribed for severe body infections.
Cilanem 1gm Injection is typically prescribed for the treatment of serious lower respiratory, intra-abdominal, urinary tract, gynecologic, bone, joint, endocarditis, bacterial septicemia, skin and skin structure infections and polymicrobic infections.
Dosage and direction of taking Cilanem 1gm Injection
Cilanem 1gm Injection should only be administered under the supervision of your doctor or nurse.
It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes.
Do not miss any pre-scheduled appointments for receiving the Injection. The course of the medicine should be completed even if you feel better.
IMPORTANT: DO NOT self administer this medicine.
The dosage is based on your weight, medical condition, and response to treatment including other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Avoid drinking alcohol while taking Cilanem 1gm Injection. Alcohol can cause excessive drowsiness with this medicine.
How Cilanem 1gm Injection work
Cilanem 1gm Injection contains equal quantities of imipenem and cilastatin [1000mg/1000mg]. Imipenem and cilastatin has the ability to kill a wide variety of bacteria. Imipenem is an active antibiotic agent which works not allowing bacteria to form cell walls, thereby making the bacteria break up and die.
Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. However, Imipenem is easily broken down by renal enzyme dehydropeptidase when injected alone which may cause kidney damage aswell, thus making it less effective. Due to this it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration ability of imipenem. Imipenem with cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. viridans- group streptococci, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species.
Precautions while taking Cilanem 1gm Injection
Tell your doctor if you are
allergic to imipenem, cilastatin, or any other part of this drug.
allergic to penicillin as this medicine should be avoided or used with caution in penicillin allergy.
allergic to any medicine. Make sure to tell about the allergy and what signs you had.
having any rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs
IMPORTANT: Further tell the doctor, if you:
have or had any kidney disease or liver disease.
have brain disorders; such as histroy of seizures, head injury, or tumor
have CNS disorders
Stomach or intestinal diseases such as colitis
have meningitis
have renal or hepatic impairment
Alcohol can cause excessive drowsiness with this medicine.
This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and baby.
If you are pregnant already, or breastfeeding think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine
This medicine is not recommended for neonates less than 3 months; The doctor will give the right dose depends on your child's age and disease
About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Cilanem may affect the way other medicines or products work, and other medicines or products may affect how Cilanem works.
Side Effects of taking Cilanem 1gm Injection
Like all medicines, this medicine can cause side effects, although not everybody gets them. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Common side effects for both forms are:
Upset stomach
Vomiting
Stomach pain
Major side effects requiring medical attention:
Diarrhea
Rash
Fever
Facial swelling
Difficulty breathing
Unusual bleeding
Hallucination
Fungal infection due to yeast
Bilirubin level increased
Low blood pressure
Increased blood platelets
Creatinine
Increased in transaminase
Reduced level of all types of blood cells
Seizures
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Drug interaction with Cilanem 1gm Injection
Inform your doctor about any medications that you are taking including prescription medications, over the counter medications, vitamins, supplements and herbal remedies. Do not start, stop and change the dosage of any medicine without your doctor's permission.
Avoid taking alcohol while you are taking Cilanem injection.
IMPORTANT: Inform the doctor, if you are currently taking any of the following medicines:
ganciclovir which increased risk of seizures
Valproic acid or sodium valproate (used to treat epilepsy)
Probenecid (used to treat gout)
If you are taking any of these medicines, tell your doctor immediately. Taking these medicines with Cilanem could create the potential for serious and/or life-threatening side-effects or stop Cilanem from working properly.
Cilanem injection should not be used if you have the following conditions
kidney, urinary and liver problems
gastrointestinal diseases
hypersensitivity to Cilnem or to any of its active ingredients
inflammation in the large intestines
convulsions
Storage of Cilanem 1gm Injection
Keep this medicine out of the sight and reach of children.
Store at 15°C - 30°C (59°F - 77°F); protect drug from excessive light, humidity, and temperature over 30°C (86°F)
Keep Cilanem 1gm Injection in the container till you handover to your health provider.
Throw away any Injection that are no longer needed or expired (out of date).
Medicines should not be disposed of via waste water or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help to protect the environment.
Cilanem 1gm Injection should not be used after the given expiration date.
Scientific Information about Cilanem 1000mg/1000mg Injection or Generic Zerit
Cilanem 1000mg/1000mg Injection is a combination of Imipenem (Carbapenem antibiotic) with Cilastatin (Dehydropeptidase inhibitor)
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