How to take Estradiol (Estrace 1 mg)?
Take Estradiol (Estrace 1 mg) exactly as it was prescribed for you. Do not take in doses which are either larger or for longer than recommended by your doctor.

Take one capsule of Estradiol (Estrace 1 mg)once a day orally with a full glass of water or as prescribed by doctor. Take it as a whole unless it is extended release tablet which has a scoreline.

Estradiol (Estrace 1 mg) can be taken with or without food. You may even take it right after a meal in order to prevent stomach upset.

Always try to take Estradiol (Estrace 1 mg) at the same time every day. If you missed a dose take Eserace as soon as you remember.  If it is too close to your next dose then skip the missed dose and take the regular dose. Should never double the dose in order to make up for the missed dose.

If you are prescribed the extended release tablets of Estradiol (Estrace 1 mg), do not crush, break or chew the tablet. This way it can release all of the drug at once which in return can increase the side effects.

If your condition doesn't improve or if it gets worse, inform your doctor immediately.

Precautions
Prior to taking Estradiol (Estrace 1 mg) 1 mg or 1mg inform your doctor if you

• have any allergies to Estradiol (Estrace 1 mg) or any of its ingredients or any other allergy
• have vaginal bleeding
• have breast cancer
• have cancer in the uterus / ovaries
• have blood clots
• have had a stroke
• have heart disease (heart attack)
• have kidney disease
• have liver disease
• have diabetes
• have high blood pressure
• have hypothyroidism (underactive thyroid)
• have lupus
• have asthma
• have seizures
• have uterus problems (endometriosis, fibroids)
• are obese
• have blood clotting disorders (protein S or C deficiency)
• have mineral imbalance (low or high calcium in the blood)
• have migraine headaches
• have porphyria (a blood disorder)
• have depression or dementia

Inform your doctor if you have just had or planning to have surgery. You may have to stop taking this medication as it may increase the risk of getting blood clots.

Inform your doctor of all prescribed, over the counter, herbal medications and vitamin supplements that you are taking before you start Estradiol (Estrace 1 mg).

Usage of tobacco or smoking is prohibited as estrogen and smoking combined it further increases the risk of having blood clots, heart attack, stroke, high blood pressure especially women who are above 35 years.

If you are wearing contact lenses or near sighted you may develop vision problems or have trouble wearing contact lenses. Your eye doctor needs to be informed of these issues.

You need to limit your time in the sun as you may get melasma (dark and blotchy areas) on your face and skin. Tanning booths and sun lamps should be avoided. Wear protective clothing and sun screen whenever you expose yourself to the sun. 

Estradiol (Estrace 1 mg) is not recommended for use in pregnant women as it may cause harm to the fetus.

Estradiol (Estrace 1 mg) is not recommended for use in breast feeding women as it may harm the baby.

Side Effects
Most people do not experience any serious side effects. However, you may experience the following side effects.

• breast tenderness
• stomach upset
• weight changes
• nausea / vomiting
• headache

Inform your doctor immediately if you experience any of the serious side effects mentioned below.

• lumps in the breast
• mood changes (depression or dementia)
• unusual vaginal bleeding
• severe abdominal or stomach pain
• vaginal discharge increased
• dark urine
• yellowing skin/eyes
•  increased thirst
• trouble breathing
• slurred speech
• Increased urination
• pain in the legs
• sudden dizziness
• coughing up blood

Inform your doctor immediately if you develop any allergic reactions (hives, swollen throat, lips, face or mouth, breathing difficulties)

Interactions
Inform your doctor if you are taking any of these medications, before you start Estradiol (Estrace 1 mg)

• aromatase inhibitors (letrosole, exemestance, anastrolole)
• tamoxifen
• fulvestrant
• raloxifene
• ospemifene
• tranexamic acid

Some laboratory tests (eg: metyrapone test) may be interfered by this medication.  Make sure all the doctors and laboratory assistants are informed  well in advance about  it.